If macroing is the worry, both still makes it easy to macro. Having it on a hotkey you can press vs a left click option does not change the macro options. Heck Kruo if you really want I can help you make a macro where you can press a key that makes it left click that icon and doesn't move the mouse.
Pretty sure that is allowed, from my understanding AFK macroing is not allowed, plus the ability to track a macro would be super hard. (When I say macro, I'm not talking about AFK macroing.)